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Generated: July 21, 2019

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Patent: 6,660,477

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Summary for Patent: 6,660,477
Title: Method for the determination of data for the preparation of the diagnosis of phakomatosis
Abstract:The invention concerns a method for the determination of data for the preparation of presymptomatic or prenatal diagnosis of phakomatosis, in particular, a tumor suppressor gene disease, in a high-risk patient, in particular of neurofibromatosis, comprising the steps of: making available the tumor material from a person afflicted with the tumor suppressor gene disease, who is a relative of the high-risk patient; isolating tumor DNA from the tumor in the relative; isolating blood DNA from the blood of the relative; amplifying polymorphous DNA microsatellite markers from the tumor and the blood; separating the markers by length; observing the lengths of the markers; comparing the markers from the blood and the tumor; examining for a loss of alleles; optionally, comparing amplified markers from a second tumor of the relative; and amplifying polymorphous DNA microsatellite markers from the blood of an offspring and separating and observing the markers.
Inventor(s): Kluwe; Lan (Hamburg, DE)
Assignee: Von Recklinghausen Gesellschaft E.V. (Hamburg, DE)
Application Number:09/893,237
Patent Claims:see list of patent claims

Details for Patent 6,660,477

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up Von Recklinghausen Gesellschaft E.V. (Hamburg, DE) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up Von Recklinghausen Gesellschaft E.V. (Hamburg, DE) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up Von Recklinghausen Gesellschaft E.V. (Hamburg, DE) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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US Department of Justice

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