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Last Updated: July 11, 2020

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Patent: 6,652,854

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Summary for Patent: 6,652,854
Title: Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L
Abstract:The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of treating conditions resistant to treatment with TNF.alpha. inhibitors by administering agents that inhibit signal transduction by CD30 or IL-1. Included also are treatments involving concurrently administering agents that block the CD30/CD30L interaction and agents that antagonize the IL-4/IL-4R interaction. Additionally provided is an animal model for screening candidate agents for their efficacy in treating conditions that are resistant to treatment with TNF.alpha. inhibitors.
Inventor(s): Mohler; Kendall M. (Poulsbo, WA), Barone; Dauphine S. (Everett, WA), Kennedy; Mary K. (Seattle, WA)
Assignee: Immunex Corporation (Seattle, WA)
Application Number:09/921,667
Patent Claims:see list of patent claims

Details for Patent 6,652,854

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial Immunex Corporation (Seattle, WA) 2020-08-08 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial Immunex Corporation (Seattle, WA) 2020-08-08 RX Orphan search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial Immunex Corporation (Seattle, WA) 2020-08-08 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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