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Last Updated: October 1, 2020

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Patent: 6,645,974

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Summary for Patent: 6,645,974
Title: Androgen receptor modulators and methods for use thereof
Abstract:Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, arthritis and joint repair, alone or in combination with other active agents. In addition, these compounds are useful as pharmaceutical composition ingredients alone and in combination with other active agents.
Inventor(s): Hutchinson; John H. (La Jolla, CA), Breslin; Michael J. (Drexel Hill, PA), Rodan; Gideon A. (Bryn Mawr, PA), Sahoo; Soumya P. (Old Bridge, NJ), Duggan; Mark E. (Schwenksville, PA), Harada; Shun-Ichi (Ambler, PA), Schmidt; Azriel (Bryn Mawr, PA), Halczenko; Wasyl (Lansdale, PA), Towler; Dwight A. (Brentwood, MO)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:10/205,634
Patent Claims:see list of patent claims

Details for Patent 6,645,974

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Merck & Co., Inc. (Rahway, NJ) 2021-07-31 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Merck & Co., Inc. (Rahway, NJ) 2021-07-31 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Merck & Co., Inc. (Rahway, NJ) 2021-07-31 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Merck & Co., Inc. (Rahway, NJ) 2021-07-31 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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