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Generated: July 17, 2019

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Patent: 6,627,189

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Summary for Patent: 6,627,189
Title: Inhibition of cellular proliferation using ras antisense molecules
Abstract:Disclosed are methods and compositions for the selective inhibition gene expression through the application of antisense RNA technology. Antisense RNA constructs of the present invention employ the use of antisense intron DNA corresponding to distinct intron regions of the gene whose expression is targeted for down-regulation. In an exemplary embodiment, a human lung cancer cell line (NCI-H460a) with a homozygous spontaneous K-ras mutation was transfected with a recombinant plasmid that synthesizes a genomic segment of K-ras in antisense orientation. Translation of the mutated K-ras mRNA was specifically inhibited, whereas expression of H-ras and N-ras was unchanged. A three-fold growth inhibition occurred in H460a cells when expression of the mutated ras p21 protein was down-regulated by antisense RNA and cells remained viable. The growth of H460a tumors in nu/nu mice was substantially reduced by expressed K-ras antisense RNA.
Inventor(s): Roth; Jack A. (Houston, TX), Mukopadhyay; Tapas (Houston, TX), Tainsky; Michael (Houston, TX)
Assignee: Board of Regents, The University of Texas Systems (Austin, TX)
Application Number:08/459,699
Patent Claims:see list of patent claims

Details for Patent 6,627,189

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up Board of Regents, The University of Texas Systems (Austin, TX) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up Board of Regents, The University of Texas Systems (Austin, TX) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up Board of Regents, The University of Texas Systems (Austin, TX) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 6,627,189

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 9215680 Sep 17, 1992
World Intellectual Property Organization (WIPO) 9512660 Aug 03, 1995
World Intellectual Property Organization (WIPO) 9512660 May 11, 1995
World Intellectual Property Organization (WIPO) 9528948 Nov 02, 1995
United States of America 2003012770 Jan 16, 2003
Country Patent Number Publication Date

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