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Last Updated: December 6, 2021

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Patent: 6,613,278

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Summary for Patent: 6,613,278
Title: Tissue pooling process
Abstract:This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
Inventor(s): Mills; C. Randal (Alachua, FL), Wironen; John F. (Alachua, FL), Hanstke; Sean (Woodbridge, CA), Donda; Russell S. (Alachua, FL), Grooms; Jamie M. (Alachua, FL), Bianchi; John (Alachua, FL)
Assignee: Regeneration Technologies, Inc. (Alachua, FL)
Application Number:09/390,174
Patent Claims:see list of patent claims

Details for Patent 6,613,278

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live For Injection 125123 2006-05-25 ⤷  Free Forever Trial 2018-11-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Express Scripts
Johnson and Johnson

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