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Last Updated: September 18, 2020

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Patent: 6,604,698

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Summary for Patent: 6,604,698
Title: Media milling
Abstract:This invention describes a process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of (a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein the exit screen comprises openings of size S.sub.0 ; the large size media have a size distribution S.sub.1 of which all are larger than S.sub.0 ; the small size media have a size distribution S.sub.2 which are smaller than S.sub.0 ; the very small milled substrate particles have a size distribution S.sub.3 and are smaller than all of the small media; and the large size media and the small size media are essentially retained in the milling chamber.
Inventor(s): Verhoff; Frank H. (Cincinnati, OH), Snow; Robert A. (West Chester, PA), Pace; Gary W. (Raleigh, NC)
Assignee: SkyePharma Canada, Inc. (Montreal, CA)
Application Number:09/852,054
Patent Claims:see list of patent claims

Details for Patent 6,604,698

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Lilly HUMATROPE somatropin INJECTABLE;INJECTION 019640 001 1987-06-23   Start Trial SkyePharma Canada, Inc. (Montreal, CA) 2020-05-10 RX search
Lilly HUMATROPE somatropin INJECTABLE;INJECTION 019640 004 1987-06-23   Start Trial SkyePharma Canada, Inc. (Montreal, CA) 2020-05-10 RX search
Lilly HUMATROPE somatropin INJECTABLE;INJECTION 019640 005 1987-06-23   Start Trial SkyePharma Canada, Inc. (Montreal, CA) 2020-05-10 RX search
Lilly HUMATROPE somatropin INJECTABLE;INJECTION 019640 006 1987-06-23   Start Trial SkyePharma Canada, Inc. (Montreal, CA) 2020-05-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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