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Last Updated: September 28, 2020

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Patent: 6,551,590

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Summary for Patent: 6,551,590
Title: Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vireous body of the eye
Abstract:The invention provide a method for accelerating the clearance of hemorrhagic blood from the vitreous humor of a mammalian eye without producing toxicity to the eye, the method comprising contacting with the vitreous humor an amount of a solution which contains hyaluronidase to provide a dose of at least 1 International Unit of hyaluronidase, the hyaluronidase being in purified form possessing intravitreal hemorrhage-clearing activity and being free from impurities that produce toxicity to the eye.
Inventor(s): Karageozian; Hampar L. (San Juan Capistrano, CA), Karageozian; Vicken H. (San Juan Capistrano, CA), Kenney; Maria Cristina (Malibu, CA), Gutierrez Flores; Jose Luis (Tijuana, MX), Carpio Aragon; Gabriel Arturo (Tijuana, MX), Nesburn; Anthony B. (Malibu, CA)
Assignee: ISTA Pharmaceuticals, Inc. (Irvine, CA)
Application Number:09/453,012
Patent Claims:see list of patent claims

Details for Patent 6,551,590

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 001 2004-12-21   Start Trial ISTA Pharmaceuticals, Inc. (Irvine, CA) 2015-11-22 RX search
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 002 2004-12-21   Start Trial ISTA Pharmaceuticals, Inc. (Irvine, CA) 2015-11-22 RX search
Amphastar Pharm AMPHADASE hyaluronidase INJECTABLE;INJECTION 021665 001 2005-11-03   Start Trial ISTA Pharmaceuticals, Inc. (Irvine, CA) 2015-11-22 RX search
Akorn Inc HYDASE hyaluronidase INJECTABLE;INJECTION 021716 001 2005-10-25   Start Trial ISTA Pharmaceuticals, Inc. (Irvine, CA) 2015-11-22 DISCN search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial ISTA Pharmaceuticals, Inc. (Irvine, CA) 2015-11-22 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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