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Last Updated: October 2, 2023

Patent: 6,548,735

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Summary for Patent: 6,548,735
Title: Production of heterologous protein in milk of transgenic non-human mammals comprising a construct with an intron
Abstract:Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5\'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5\'-flanking sequence is sufficient to drive expression of the heterologous protein.
Inventor(s): Archibald; Alan Langskill (Edinburgh, GB), Clark; Anthony John (Midlothian, GB)
Assignee: PPL (Holdings) Limited (London, GB)
Application Number:08/781,518
Patent Claims:see list of patent claims

Details for Patent 6,548,735

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2008-11-11
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2008-11-11
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2008-11-11
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

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