Heterocyclic containing biphenyl aP2 inhibitors and method
aP2 inhibiting compounds are provided having the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X-Z and ##STR2## are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.
Robl; Jeffrey A. (Newtown, PA), Sulsky; Richard B. (West Trenton, NJ), Magnin; David R. (Hamilton, NJ)
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