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Last Updated: January 17, 2021

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Patent: 6,537,520

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Summary for Patent: 6,537,520
Title: Pharmaceuticals for the imaging of angiogenic disorders
Abstract:The present invention describes novel compounds of the formula: useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
Inventor(s): Rajopadhye; Milind (Westford, MA), Edwards; D. Scott (Burlington, MA), Barrett; John A. (Groton, MA), Carpenter, Jr.; Alan P. (Carlisle, MA), Harris; Thomas D. (Samel, NH), Heminway; Stuart J. (Lowell, MA), Liu; Shuang (Chelmsford, MA), Singh; Prahlad R. (Arlington, MA)
Assignee: Bristol-Myers Squibb Pharma Company (Princeton, NJ)
Application Number:09/599,295
Patent Claims:see list of patent claims

Details for Patent 6,537,520

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Eisai Inc ONTAK denileukin diftitox VIAL 103767 001 1999-02-05   Start Trial Bristol-Myers Squibb Pharma Company (Princeton, NJ) 2018-03-31 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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