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Last Updated: December 8, 2019

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Patent: 6,531,477

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Summary for Patent: 6,531,477
Title: 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
Abstract:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II): ##STR1## that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
Inventor(s): Markwalder; Jay A. (London University, PA), Seitz; Steven P. (Swarthmore, PA), Sherk; Susan R. (Wilmington, DE)
Assignee: DuPont Pharmaceuticals Company (Wilmington, DE)
Application Number:09/416,584
Patent Claims:see list of patent claims

Details for Patent 6,531,477

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Sigma Tau ONCASPAR pegaspargase VIAL 103411 001 1994-02-01   Start Trial DuPont Pharmaceuticals Company (Wilmington, DE) 2018-10-13 RX search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial DuPont Pharmaceuticals Company (Wilmington, DE) 2018-10-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 6,531,477

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