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Last Updated: September 28, 2020

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Patent: 6,521,815

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Summary for Patent: 6,521,815
Title: Animal model system for squamous cell carcinoma
Abstract:Non-human mammalian animals having a higher epidermal expression level of protein kinase C.epsilon. than their wild-type counterparts are phenotypically distinguished from wild-type animals in that the animals induced to develop tumors in a chemical initiation/promotion protocol are suppressed for subsequent papilloma development but are susceptible to developing squamous cell carcinoma and metastatic squamous cell carcinoma. The animals are advantageously used in methods for screening putative agents for altering the susceptibility, development and progression of squamous cell carcinoma and metastatic squamous cell carcinoma and have further commercial value as tools for investigating the development of metastatic disease.
Inventor(s): Verma; Ajit K. (Madison, WI), Reddig; Peter J. (Durham, NC), Jansen; Aaron P. (New Market, MD)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Application Number:09/772,647
Patent Claims:see list of patent claims

Details for Patent 6,521,815

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Wisconsin Alumni Research Foundation (Madison, WI) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Wisconsin Alumni Research Foundation (Madison, WI) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Wisconsin Alumni Research Foundation (Madison, WI) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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