DrugPatentWatch Database Preview
Patent: 6,500,647
Summary for Patent: 6,500,647
| Title: | Recombinant expression vector of human parathyroid hormone |
| Abstract: | The present invention relates to a recombinant expression vector which is prepared by inserting a human parathyroid hormone gene containing a urokinase-specific cleavage site into an L-arabinose inducible vector containing a phosphoribulokinase gene fragment of Rhodabacter sphaeroides or its mutated gene as a fusion partner, or its mutate gene as a fusion partner, a recombinant microorganism transformed with the said expression vector, and a process for preparing human parathyroid hormone on a large scale by cultivating the said microorganism in a medium containing L-arabinose. In accordance with the invention, a recombinant human PTH having the same activity of the native human PTH can be prepared in a high yield through the precise control of induction by a manufacturing process which comprises a step of inducing expression of fusion protein in the microorganism transformed with the recombinant expression vector by L-arabinose. |
| Inventor(s): | Jung; Eun-Kyung (Seoul, KR), Park; Doo-Hong (Seoul, KR), Chung; Soo-Il (Sungnam-si, KR) |
| Assignee: | Mogam Biotechnology Research Institute (Kyonggi-Do, KR) |
| Application Number: | 09/463,282 |
| Patent Claims: | see list of patent claims |
Details for Patent 6,500,647
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 001 | 2015-01-23 | Start Trial | Mogam Biotechnology Research Institute (Kyonggi-Do, KR) | 2017-07-25 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 002 | 2015-01-23 | Start Trial | Mogam Biotechnology Research Institute (Kyonggi-Do, KR) | 2017-07-25 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 003 | 2015-01-23 | Start Trial | Mogam Biotechnology Research Institute (Kyonggi-Do, KR) | 2017-07-25 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 004 | 2015-01-23 | Start Trial | Mogam Biotechnology Research Institute (Kyonggi-Do, KR) | 2017-07-25 | RX | Orphan | search |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
