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Generated: September 23, 2019

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Patent: 6,500,647

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Summary for Patent: 6,500,647
Title: Recombinant expression vector of human parathyroid hormone
Abstract:The present invention relates to a recombinant expression vector which is prepared by inserting a human parathyroid hormone gene containing a urokinase-specific cleavage site into an L-arabinose inducible vector containing a phosphoribulokinase gene fragment of Rhodabacter sphaeroides or its mutated gene as a fusion partner, or its mutate gene as a fusion partner, a recombinant microorganism transformed with the said expression vector, and a process for preparing human parathyroid hormone on a large scale by cultivating the said microorganism in a medium containing L-arabinose. In accordance with the invention, a recombinant human PTH having the same activity of the native human PTH can be prepared in a high yield through the precise control of induction by a manufacturing process which comprises a step of inducing expression of fusion protein in the microorganism transformed with the recombinant expression vector by L-arabinose.
Inventor(s): Jung; Eun-Kyung (Seoul, KR), Park; Doo-Hong (Seoul, KR), Chung; Soo-Il (Sungnam-si, KR)
Assignee: Mogam Biotechnology Research Institute (Kyonggi-Do, KR)
Application Number:09/463,282
Patent Claims:see list of patent claims

Details for Patent 6,500,647

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Sign Up Mogam Biotechnology Research Institute (Kyonggi-Do, KR) 2017-07-25 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Sign Up Mogam Biotechnology Research Institute (Kyonggi-Do, KR) 2017-07-25 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Sign Up Mogam Biotechnology Research Institute (Kyonggi-Do, KR) 2017-07-25 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Sign Up Mogam Biotechnology Research Institute (Kyonggi-Do, KR) 2017-07-25 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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