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Generated: September 16, 2019

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Patent: 6,492,106

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Summary for Patent: 6,492,106
Title: Mammalian proteins that bind to FKBP12 in a rapamycin-dependent fashion
Abstract:A protein complex containing 245 kDa and 35 kDa components, designated RAFT1 and RAFT2 (for Rapamycin And FKBP12 Target) interacts with FKBP12 in a rapamycin-dependent manner. This interaction has the pharmacological characteristics expected from the observed in vivo effects of rapamycin: it occurs at low nanomolar concentrations of rapamycin and is competed by excess FK506. Sequences (330 amino acids total) of tryptic peptides derived from the affinity purified 245 kDa RAFT1 reveals striking homologies to the predicted products of the yeast TOR genes, which were originally identified by mutations that confer rapamycin resistance in yeast. A RAFT1 cDNA was obtained and found to encode a 289 kDa protein (2550 amino acids) that is 43% and 39% identical to TOR2 and TOR1, respectively.
Inventor(s): Sabatini; David M. (Baltimore, MD), Erdjument-Bromage; Hediye (New York, NY), Lui; Mary (Kew Gardens, NY), Tempst; Paul (New York, NY), Snyder; Solomon H. (Baltimore, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Application Number:08/305,790
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,492,106
Patent Claims:see list of patent claims

Details for Patent 6,492,106

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Try a Free Trial The Johns Hopkins University (Baltimore, MD) 2019-12-10 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Try a Free Trial The Johns Hopkins University (Baltimore, MD) 2019-12-10 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Try a Free Trial The Johns Hopkins University (Baltimore, MD) 2019-12-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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