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Last Updated: August 11, 2020

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Patent: 6,451,552

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Summary for Patent: 6,451,552
Title: Method for the selective degradation of milk protein in the presence of other milk proteins
Abstract:A method is presented for producing a casein/caseinate hydrolysate stripped of immunogenic proteins. The method comprises treating an aqueous solution, such as milk, comprising casein/caseinate and immunogenic protein other than casein with a protease that selectively hydrolyzes casein. After the casein/caseinate has been hydrolyzed, the casein/caseinate hydrolyzate is separated by membrane ultrafiltration from unhydrolyzed immunogenic protein and recovered. The resulting hydrolyzate is essentially free of antigenic components of the ABBOS peptide and bovine serum albumin. The casein selective protease is selected from cell wall proteinase of Lactococcus lactis subsp. Cremoris Wg2, a Clostridium histolyticum collagenase and a Bacillus polymyxa dispase.
Inventor(s): Van Beresteijn; Emmerentia Catharine Henriette (Ede, NL), Alting; Aart Cornelis (Ede, NL)
Assignee: Nederlands Instituut voor Zuivelonderzoek (NL)
Application Number:09/341,785
Patent Claims:see list of patent claims

Details for Patent 6,451,552

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Nederlands Instituut voor Zuivelonderzoek (NL) 2017-01-17 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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