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Last Updated: November 29, 2021

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Patent: 6,451,534

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Summary for Patent: 6,451,534
Title: KVLQT1--a long QT syndrome gene
Abstract:The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes ARE also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.
Inventor(s): Keating; Mark T. (Salt Lake City, UT), Sanguinetti; Michael C. (Salt Lake City, UT), Curran; Mark E. (Encinitas, CA), Landes; Gregory M. (Northboro, MA), Connors; Timothy D. (Hopkinton, MA), Burn; Timothy C. (Hockessin, DE), Splawski; Igor (Salt Lake City, UT)
Assignee: University of Utah Research Foundation (Salt Lake City, UT) Genzyme Corporation (Framingham, MA)
Application Number:09/597,732
Patent Claims:see list of patent claims

Details for Patent 6,451,534

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2015-12-22
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2015-12-22
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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