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Generated: July 23, 2019

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Patent: 6,428,771

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Summary for Patent: 6,428,771
Title: Method for drug delivery to the pulmonary system
Abstract:Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0.5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6.4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6.4 or less and unstable at pH of greater than 6.4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6.4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.
Inventor(s): Steiner; Solomon S. (Mt. Kisco, NY), Feldstein; Robert (Dobbs Ferry, NY), Lian; Huiling (Yonkers, NY), Rhodes; Christopher A. (Stamford, CT), Shen; Gregory S. (Hartsdale, NY)
Assignee: Pharmaceutical Discovery Corporation (Elmsford, NY)
Application Number:08/441,378
Patent Claims:see list of patent claims

Details for Patent 6,428,771

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Sign Up Pharmaceutical Discovery Corporation (Elmsford, NY) ➤ Sign Up RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Sign Up Pharmaceutical Discovery Corporation (Elmsford, NY) ➤ Sign Up RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Sign Up Pharmaceutical Discovery Corporation (Elmsford, NY) ➤ Sign Up RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Sign Up Pharmaceutical Discovery Corporation (Elmsford, NY) ➤ Sign Up RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 6,428,771

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 9636314 Feb 06, 1997
World Intellectual Property Organization (WIPO) 9636314 Nov 21, 1996
United States of America 2003017211 Jan 23, 2003
United States of America 2004096403 May 20, 2004
United States of America 6071497 Jun 06, 2000
United States of America 8394414 Mar 12, 2013
Australia 5740996 Nov 29, 1996
Country Patent Number Publication Date

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Serving hundreds of leading biopharmaceutical companies globally:

Fuji
Fish and Richardson
McKesson
Chinese Patent Office
Boehringer Ingelheim
QuintilesIMS

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