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Last Updated: October 1, 2020

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Patent: 6,426,075

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Summary for Patent: 6,426,075
Title: Protease-activatable pseudomonas exotoxin A-like proproteins
Abstract:This invention provides protease-activatable Pseudomonas exotoxin A-like (\"PE-like\") proproteins. The proproteins comprise (1) a cell recognition domain of between 10 and 1500 amino acids that binds to a cell surface receptor; (2) a modified PE translocation domain comprising an amino acid sequence sufficiently homologous to domain II of PE to effect translocation to a cell cytosol upon proteolytic cleavage, wherein the translocation domain comprises a cysteine-cysteine loop that comprises a protease activatable sequence cleavable by a protease and wherein the cysteine-cysteine loop is substantially un-activatable by furin; (3) optionally, a PE Ib-like domain comprising an amino acid sequence up to 1500 amino acids; (4) a cytotoxicity domain comprising an amino acid sequence substantially homologous to domain III of PE, the cytotoxicity domain having ADP-ribosylating activity; and (5) an endoplasmic reticulum (\"ER\") retention sequence. The invention also provides methods of using these proproteins for killing target cells.
Inventor(s): Fitzgerald; David J. (Rockville, MD), Reiter; Yoram (Ness Ziona, IL), Pastan; Ira (Potomac, MD)
Assignee: The United States of America as represented by the Secretary of the (N/A) (Washington, DC)
Application Number:09/297,851
Patent Claims:see list of patent claims

Details for Patent 6,426,075

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial The United States of America as represented by the Secretary of the (N/A) (Washington, DC) 2016-11-06 RX search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial The United States of America as represented by the Secretary of the (N/A) (Washington, DC) 2016-11-06 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial The United States of America as represented by the Secretary of the (N/A) (Washington, DC) 2016-11-06 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial The United States of America as represented by the Secretary of the (N/A) (Washington, DC) 2016-11-06 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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