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Last Updated: September 27, 2020

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Patent: 6,413,511

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Summary for Patent: 6,413,511
Title: Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide
Abstract:The subject invention concerns a method of introducing at least one DNA sequence expressing a protein or protein fragment which substantially alleviates articular cartilage defects. This method involves in vitro culture of chondrocytes, transfection of the chondrocytes with a recombinant vector housing the DNA sequence to be expressed, and delivery of the transfected chondrocytes to the damaged cartilage region. This method can also be used in tandem with synovial cell delivery techniques of the present invention. This method is also useful as a model in animal studies regarding joint pathologies.
Inventor(s): Glorioso; Joseph C. (Cheswick, PA), Evans; Christopher H. (Pittsburgh, PA), Robbins; Paul D. (Pittsburgh, PA), Kane; Richard (Pittsburgh, PA)
Assignee: University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, PA)
Application Number:08/466,932
Patent Claims:see list of patent claims

Details for Patent 6,413,511

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial University of Pittsburgh of the Commonwealth System of Higher Education (Pittsburgh, PA) 2019-07-02 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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