Make Better Decisions - Finding and Evaluating Generic and Branded Drug Market Entry Opportunities

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Generated: July 23, 2019

DrugPatentWatch Database Preview

Patent: 6,407,103

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Summary for Patent: 6,407,103
Title: Indeno [1,2-c] pyrazol-4-ones and their uses
Abstract:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): ##STR1## that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
Inventor(s): Nugiel; David A. (Cherry Hill, NJ), Carini; David J. (Wilmington, DE), Di Meo; Susan V. (Wilmington, DE), Yue; Eddy W. (Landenberg, PA)
Assignee: Bristol-Myers Squibb Pharma Company (Wilmington, DE)
Application Number:09/731,304
Patent Claims:see list of patent claims

Details for Patent 6,407,103

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Sigma Tau ONCASPAR pegaspargase VIAL 103411 001 1994-02-01 ➤ Sign Up Bristol-Myers Squibb Pharma Company (Wilmington, DE) ➤ Sign Up RX search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ➤ Sign Up Bristol-Myers Squibb Pharma Company (Wilmington, DE) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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