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Last Updated: December 5, 2021

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Patent: 6,399,086

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Summary for Patent: 6,399,086
Title: Pharmaceutical preparations for the controlled release of beta-lactam antibiotics
Abstract:The present invention relates to a pharmaceutical controlled-release oral drug delivery system comprising as active ingredient at least one .beta.-lactam antibiotic agent, having a specific absorption site in the small intestine in combination with a polymeric matrix, optionally further containing additional pharmaceutically acceptable constituents, wherein at least 50% of the .beta.-lactam antibiotic agent are released from the matrix within from about 3 to about 4 hours from oral administration and the reminder of the pharmaceutical agent is released at a controlled rate. The drug delivery system according to the invention optionally further comprises a .beta.-lactamase inhibitor, preferably in combination with amoxicillin and/or amoxicillin trihydrate as the active ingredient. The polymeric matrix of the pharmaceutical controlled-release oral drug delivery system of the invention my be of hydrophilic and/or hydrophobic nature and the delivery system may further comprise pharmaceutically acceptable additive. The pharmaceutical controlled-release oral drug delivery system of the invention is preferably in dosage unit form.
Inventor(s): Katzhendler; Ifat (Jerusalem, IL), Hoffman; Amnon (Jerusalem, IL), Friedman; Michael (Jerusalem, IL)
Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem (Jerusalem, IL)
Application Number:09/313,101
Patent Claims:see list of patent claims

Details for Patent 6,399,086

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 1942-10-21 ⤷  Try it Free 2016-11-17
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 1954-03-03 ⤷  Try it Free 2016-11-17
Csl Behring Ag ALBURX albumin (human) Injection 102366 1976-07-23 ⤷  Try it Free 2016-11-17
Grifols Biologicals Llc ALBUTEIN albumin (human) Injection 102478 1978-08-15 ⤷  Try it Free 2016-11-17
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 1995-02-17 ⤷  Try it Free 2016-11-17
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 2003-06-11 ⤷  Try it Free 2016-11-17
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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