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Last Updated: September 22, 2020

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Patent: 6,361,998

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Summary for Patent: 6,361,998
Title: Efficient culture of stem cells for the production of hemoglobin
Abstract:The present invention describes a serum-free medium that promotes the growth and differentiation of erythroid cells, cells that are highly transducible by a non-viral method and genes which increase the growth of erythroid cells and decrease their dependency on Epo. This invention can be used in the expansion of hematopoietic stem cells to produce cultures of erythroid cells as a source of erythroid-specific proteins such as hemoglobin. Hematopoietic stem cells are cultured ex vivo in a serum-free culture medium with the addition of IL-3, SCF and EPO. Cells transfected with the gene described in the present invention can be cultured in the serum-free culture medium with decreased dependency on Epo and other cytokines, thereby reducing the cost of the production of hemoglobin.
Inventor(s): Bell; David N. (Oakville, CA), Matthews; Kathryn Emma (Toronto, CA), Mueller; Susan G. (Milton, CA)
Assignee: Hemosol Inc. (Mississauga, CA)
Application Number:09/339,838
Patent Claims:see list of patent claims

Details for Patent 6,361,998

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Recordati Rare Diseases, Inc. PANHEMATIN hemin POWDER, FOR SOLUTION 101246 1 1983-07-20   Start Trial Hemosol Inc. (Mississauga, CA) 2040-01-28 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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