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Last Updated: July 11, 2020

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Patent: 6,358,737

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Summary for Patent: 6,358,737
Title: Osteocyte cell lines
Abstract:The present invention relates to a method of producing osteocyte cell line in various stages of differentiation. Such cell line remains stable after more than 20 passages. The osteocyte has a stellate shape with dendritic processes and expresses high level of osteocalcin. More specifically, it provides a method of production for cultured osteocytes of various differentiation stages. Furthermore, it relates to osteocyte cell line, and more specifically cultured osteocyte. The invention also relates to a method for the production of monoclonal antibodies using such cultured osteocytes and further relates to hybridomas and monoclonal antibodies which recognize an osteocyte-specific antigen. Finally, the invention relates to a method of screening for modification factors and binding factors for osteocytes.
Inventor(s): Bonewald; Lynda F (San Antonio, TX), Kato; Yoichi (Fuji, JP)
Assignee: Board of Regents, The University of Texas System (TX)
Application Number:09/152,147
Patent Claims:see list of patent claims

Details for Patent 6,358,737

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Board of Regents, The University of Texas System (TX) 2016-07-31 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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