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Last Updated: September 30, 2020

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Patent: 6,355,422

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Summary for Patent: 6,355,422
Title: Single tube PCR assay for detection of chromosomal mutations: application to the inversion hotspot in the factor VIII gene including optional use of subcycling PCR
Abstract:Methods are presented for determining the presence of an inversion in the factor VIII gene which cause hemophilia A. The methods encompass long distance, multiplex PCR (including overlapping PCR). The use of deaza-dGTP, high levels of DNA polymerases and high levels of DMSO aid in successfully performing the PCR. The use of a novel technique called subcycling PCR can also be applied as part of the methods. The technique allows for the determination of whether a person is homozygous or hemizygous for the inversion and has hemophilia A or whether a person is heterozygous for the inversion and is a carrier. The technique of long distance, multiplex PCR including use of deaza-dGTP, high levels of DNA polymerases and high levels of DMSO are applicable to the determination of the presence of other gross chromosomal aberrations such as deletions/inversions, translocations and inversions. The use of subcycling PCR can achieve efficient and more even amplification than normal two or three temperature PCR and is applicable to long distance, multiplex PCR.
Inventor(s): Liu; Qiang (Arcadia, CA), Sommer; Steve S. (Duarte, CA)
Assignee: City of Hope (Duarte, CA)
Application Number:09/200,934
Patent Claims:see list of patent claims

Details for Patent 6,355,422

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial City of Hope (Duarte, CA) 2018-06-24 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial City of Hope (Duarte, CA) 2018-06-24 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial City of Hope (Duarte, CA) 2018-06-24 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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