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Last Updated: December 7, 2021

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Patent: 6,348,316

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Summary for Patent: 6,348,316
Title: Genetic testing for determining the risk of pouchitis development
Abstract:The present invention provides a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is created in a patient with ulcerative colitis. The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele linked to an interferon .gamma. receptor locus, where the presence of the pouchitis-associated allele indicates an increased risk of pouchitis development. The interferon .gamma. receptor locus to which the pouchitis-associated allele is linked can be, for example, an interferon .gamma. receptor 1 gene. A pouchitis-associated allele useful in the invention can be, for example, an allele located within the sixth intron of the interferon .gamma. receptor 1 gene, such as a FA1 microsatellite 171 allele.
Inventor(s): Taylor; Kent D. (Santa Paula, CA), Yang; Huiyang (Cerritos, CA), Rotter; Jerome I. (Los Angeles, CA), Fleshner; Phillip R. (Beverly Hills, CA)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA)
Application Number:09/556,868
Patent Claims:see list of patent claims

Details for Patent 6,348,316

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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