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Last Updated: June 1, 2020

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Patent: 6,339,160

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Summary for Patent: 6,339,160
Title: Metalloproteinase inhibitors, their therapeutic use and process for the production of the starting compound in the synthesis thereof
Abstract:Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumoral growth and metastatization, aterosclerosis, multiple sclerosis, Alzheimer\'s disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases. Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as an initial product necessary to synthesize all compounds mentioned above.
Inventor(s): Politi; Vincenzo (Rome, IT), Gavuzzo; Enrico (Rome, IT), Gallina; Carlo (Rome, IT), Stazio; Giovanni Di (Rome, IT), D\'Alessio; Silvana (Rome, IT), Sella; Antonio (Rome, IT), Piazza; Cinzia (Rome, IT), Giordano; Cesare (Rome, IT), Gorini; Barbara (Rome, IT), Panini; Gabriella (Rome, IT), Paradisi; Mario Paglialunga (Rome, IT), Cirilli; Maurizio (Rome, IT), Pochetti; Giorgio (Rome, IT), Mazza; Fernando (Rome, IT)
Assignee: Polifarma S.p.A. (Rome, IT) Consiglio Nazionale Delle Ricerche (Rome, IT)
Application Number:09/462,932
Patent Claims:see list of patent claims

Details for Patent 6,339,160

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Polifarma S.p.A. (Rome, IT) Consiglio Nazionale Delle Ricerche (Rome, IT) 2017-07-17 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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