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Generated: September 17, 2019

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Patent: 6,313,092

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Summary for Patent: 6,313,092
Title: Method for increasing the electrotransport flux of polypeptides
Abstract:Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming .alpha.-helical or .beta.-sheet segments. In particular, amino acid residues known to stabilize .alpha.-helical and .beta.-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.
Inventor(s): Holladay; Leslie A. (Mountain View, CA), Oldenburg; Kevin R. (Fremont, CA)
Assignee: ALZA Corporation (Mountain View, CA)
Application Number:09/007,466
Patent Claims:see list of patent claims

Details for Patent 6,313,092

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Sign Up ALZA Corporation (Mountain View, CA) 2015-06-06 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Sign Up ALZA Corporation (Mountain View, CA) 2015-06-06 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Sign Up ALZA Corporation (Mountain View, CA) 2015-06-06 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Sign Up ALZA Corporation (Mountain View, CA) 2015-06-06 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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