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Last Updated: January 26, 2020

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Patent: 6,312,939

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Summary for Patent: 6,312,939
Title: Genetically engineered glutaminase and its use in antiviral and anticancer therapy
Abstract:DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anti-cancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
Inventor(s): Roberts; Joseph (Columbia, SC), MacAllister; Thomas W (Columbia, SC), Sethuraman; Natarajan (Columbia, SC), Freeman; Abbie G. (Columbia, SC)
Assignee: ME Medical Enzymes AG (St. Gallen, CH)
Application Number:08/050,482
Patent Claims:see list of patent claims

Details for Patent 6,312,939

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial ME Medical Enzymes AG (St. Gallen, CH) 2018-11-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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