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Last Updated: September 30, 2020

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Patent: 6,309,823

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Summary for Patent: 6,309,823
Title: Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
Abstract:The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set. The probes in the second, third and fourth probe sets are identical to a sequence comprising the corresponding probe from the first probe set or a subsequece of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the four probe sets.
Inventor(s): Cronin; Maureen T. (Los Altos, CA), Miyada; Charles G (San Jose, CA), Hubbell; Earl A. (Los Angeles, CA), Chee; Mark (Palo Alto, CA), Fodor; Stephen P. A. (Palo Alto, CA), Huang; Xiaohua C. (Mountain View, CA), Lipshutz; Robert J. (Palo Alto, CA), Lobban; Peter E. (Mountain View, CA), Morris; MacDonald S. (Felton, CA), Sheldon; Edward L. (San Diego, CA)
Assignee: Affymetrix, Inc. (Santa Clara, CA)
Application Number:08/778,794
Patent Claims:see list of patent claims

Details for Patent 6,309,823

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Affymetrix, Inc. (Santa Clara, CA) 2013-10-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Affymetrix, Inc. (Santa Clara, CA) 2013-10-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Affymetrix, Inc. (Santa Clara, CA) 2013-10-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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