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Last Updated: September 23, 2020

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Patent: 6,309,633

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Summary for Patent: 6,309,633
Title: Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
Abstract:The invention provides a drug-oligomer conjugate having the following general formula: ##STR1## wherein D is a therapeutic drug moiety; H and H\' are each a hydrophilic moiety, independently selected from the group consisting of straight or branched PEG polymers having from 2 to 130 PEG subunits, and sugars; L is a lipophilic moiety selected from the group consisting of alkyl groups having 2-26 carbon atoms, cholesterol, adamantane and fatty acids; o is a number from 1 to the maximum number of covalent bonding sites on H; m+n+p together have a value of at least one and not exceeding the total number of covalent bonding sites on D for the --H\', --L and --H--L substituents; the H--L bond(s) are hydrolyzable and the D--L\' bond(s), when present, are hydrolyzable; the conjugate being further characterized by one of the following: (i) m is 0 and p is at least 1; (ii) n is 0 and p is at least 1; (iii) m and n are each 0 and p is at least 1; (iv) p is 0 and m and n are each at least 1. The therapeutic drug moiety is preferably a therapeutic protein or peptide, preferably insulin or a functional equivalent thereof.
Inventor(s): Ekwuribe; Nnochiri (Cary, NC), Ramaswamy; Muthukumar (Cary, NC), Rajagopalan; Jayanthi Sethuraman (Cary, NC)
Assignee: Nobex Corporation (Research Triangle Park, NC)
Application Number:09/336,548
Patent Claims:see list of patent claims

Details for Patent 6,309,633

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial Nobex Corporation (Research Triangle Park, NC) 2039-02-26 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial Nobex Corporation (Research Triangle Park, NC) 2039-02-26 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Nobex Corporation (Research Triangle Park, NC) 2039-02-26 DISCN search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Nobex Corporation (Research Triangle Park, NC) 2039-02-26 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Nobex Corporation (Research Triangle Park, NC) 2039-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Nobex Corporation (Research Triangle Park, NC) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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