Patent: 6,291,504
✉ Email this page to a colleague
Summary for Patent: 6,291,504
| Title: | Acylsemicarbazides and their uses |
| Abstract: | The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I): ##STR1## that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents. |
| Inventor(s): | Nugiel; David A. (Cherry Hill, NJ), Carini; David J. (Wilmington, DE), Di Meo; Susan V. (Wilmington, DE), Vidwans; Anup P. (Wilmington, DE), Yue; Eddy W. (Landenberg, PA) |
| Assignee: | DuPont Pharmaceuticals Company (Wilmington, DE) |
| Application Number: | 09/692,023 |
| Patent Claims: | see list of patent claims |
Details for Patent 6,291,504
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Recordati Rare Diseases, Inc. | ELSPAR | asparaginase | For Injection | 101063 | 01/10/1978 | ⤷ Try a Trial | 2039-02-26 |
| Servier Pharmaceuticals Llc | ONCASPAR | pegaspargase | Injection | 103411 | 02/01/1994 | ⤷ Try a Trial | 2039-02-26 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
