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Last Updated: September 21, 2020

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Patent: 6,291,504

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Summary for Patent: 6,291,504
Title: Acylsemicarbazides and their uses
Abstract:The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I): ##STR1## that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
Inventor(s): Nugiel; David A. (Cherry Hill, NJ), Carini; David J. (Wilmington, DE), Di Meo; Susan V. (Wilmington, DE), Vidwans; Anup P. (Wilmington, DE), Yue; Eddy W. (Landenberg, PA)
Assignee: DuPont Pharmaceuticals Company (Wilmington, DE)
Application Number:09/692,023
Patent Claims:see list of patent claims

Details for Patent 6,291,504

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial DuPont Pharmaceuticals Company (Wilmington, DE) 2039-02-26 RX search
Sigma Tau ONCASPAR pegaspargase VIAL 103411 001 1994-02-01   Start Trial DuPont Pharmaceuticals Company (Wilmington, DE) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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