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Last Updated: September 27, 2020

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Patent: 6,284,537

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Summary for Patent: 6,284,537
Title: Immortalized human corneal epithelial cell line
Abstract:Immortalized human cornea). epithelial cell line capable of becoming stratified, and capable of expressing (1) metabolic markers specific for non-immortalized human epithelial cells such as vimentin, cytokeratins, connections between the cells, cytochrome P450s, a glutathione-S-transferase, Cu/Zn-superoxide dismutase, glutathione peroxidase, aldehyde reductase and catalase; (2) metabolic differentiation markers specific for non-immortalized human cornea). epithelial cells such as the cytokeratin of 64 kfl, the glutathione-stransferase hGST 5.8, and the profile of cytokines and growth factors comprising the compounds TNF.alpha., IL-1.beta., IL-1.alpha., IL-6, IL-8, GM CSF-.beta., IL-ra, TGF-.beta.1, TGF-.beta.2, TGF.alpha., EGF, PDGF-.beta.; (3) and markers specific for an inflammatory reaction such as collagenase I, the bradykinin, histamine and PAF receptors, and the system for transduction of an inflammatory signal by the phosphoinositides. Process for identifying the mutagenic, toxic or beneficial effect of an agent on the metabolism of the corneal cells, in which (1) an agent suspected of being a mutagenic, toxic or beneficial agent for the metabolism of the cells of the human cornea is reacted, cultured or brought into contact with a culture comprising a cell line according to the invention, and (2) the effects of the said agent on the said cell line are determined or measured.
Inventor(s): Offord Cavin; Elizabeth (Poliez-Pittet, CH), Pfeifer; Andrea M. A. (St-Legier, CH), Sharif; Najam A. (Arlington, TX), Tromvoukis; Yvonne (Mollie-Margot, CH)
Assignee: Nestec S.A. (Vevey, CH)
Application Number:08/997,588
Patent Claims:see list of patent claims

Details for Patent 6,284,537

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Nestec S.A. (Vevey, CH) 2016-12-24 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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