Patent: 6,274,354

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Summary for Patent: 6,274,354

Title:	Methods using cre-lox for production of recombinant adeno-associated viruses
Abstract:	Methods for efficient production of recombinant AAV are described. In one aspect, three vectors are introduced into a host cell. A first vector directs expression of cre recombinase, a second vector contains a promoter, a spacer sequence flanked by loxP sites and rep/cap, and a third vector contains a minigene containing a transgene and regulatory sequences flanked by AAV ITRs. In another aspect, the host cell stably or inducibly expresses cre recombinase and two vectors carrying the other elements of the system are introduced into the host cell.
Inventor(s):	Wilson; James M. (Gladwyne, PA), Phaneuf; Daniel (Philadelphia, PA)
Assignee:	The Trustees of the University of Pennsylvania (Philadelphia, PA)
Application Number:	09/242,743
Patent Claims:	see list of patent claims

Details for Patent 6,274,354

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	See Plans and Pricing	2016-09-06
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		See Plans and Pricing	2016-09-06
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		See Plans and Pricing	2016-09-06
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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