➤ Get the DrugPatentWatch Daily Briefing

Get Daily Updates on Generic Entry, Litigation, Biosimilars, and more …

Serving leading biopharmaceutical companies globally:

Dow
Medtronic
Boehringer Ingelheim
Johnson and Johnson
Merck
Baxter

Last Updated: September 27, 2020

DrugPatentWatch Database Preview

Patent: 6,265,157

➤ Get the DrugPatentWatch Daily Briefing
» See Plans and Pricing

« Back to Dashboard

Summary for Patent: 6,265,157
Title: Compositions and methods for detecting altered COL1A1 gene sequences
Abstract:Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the existence in a subject of a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided, wherein such pathological conditions include diseases and disorders which are known to be associated with an altered gene encoding a Type I or Type IX collagen protein chain. Primers, probes, and methods of detecting a genetic predisposition of a subject for a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided. Diseases and disorders for which the methods and compositions of the invention are useful for diagnostic or prognostic purposes include, but are not limited to osteoporosis, osteoarthritis, chondrodysplasia, multiple epiphyseal dysplasia, osteogenesis imperfecta, shortness of stature, scoliosis, low bone density, and degenerative joint disease.
Inventor(s): Prockop; Darwin J. (Philadelphia, PA), Spotila; Loretta D. (Haddonfield, NJ), Deltas; Constantinos D. (Nicosia, CY), Sereda; Larisa (Philadelphia, PA), Westerhausen Larson; Andrea (Forrest Hills, PA), Pack; Michael (Philadelphia, PA), Colige; Alain (Philadelphia, PA), Early; James (Upper Darby, PA), Korkko; Jarmo (Philadelphia, PA), Ala-Kokko; Leena (Oulu, FI), Annunen; Susanna (Oulu, FI), Pihlajamaa; Tero (Oulu, FI), Vuoristo; Mirko (Oulu, FI), Paassilta; Petteri (Oulu, FI)
Assignee: Allegheny University of the Health Sciences (Philadelphia, PA) Thomas Jefferson University (Philadelphia, PA) University of Oulu (Oulu, FI)
Application Number:08/943,731
Patent Claims:see list of patent claims

Details for Patent 6,265,157

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Allegheny University of the Health Sciences (Philadelphia, PA) Thomas Jefferson University (Philadelphia, PA) University of Oulu (Oulu, FI) 2011-12-03 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Allegheny University of the Health Sciences (Philadelphia, PA) Thomas Jefferson University (Philadelphia, PA) University of Oulu (Oulu, FI) 2011-12-03 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Allegheny University of the Health Sciences (Philadelphia, PA) Thomas Jefferson University (Philadelphia, PA) University of Oulu (Oulu, FI) 2011-12-03 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Merck
Moodys
Baxter
Dow
Boehringer Ingelheim
Johnson and Johnson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.