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Last Updated: December 5, 2021

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Patent: 6,265,157

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Summary for Patent: 6,265,157
Title: Compositions and methods for detecting altered COL1A1 gene sequences
Abstract:Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the existence in a subject of a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided, wherein such pathological conditions include diseases and disorders which are known to be associated with an altered gene encoding a Type I or Type IX collagen protein chain. Primers, probes, and methods of detecting a genetic predisposition of a subject for a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided. Diseases and disorders for which the methods and compositions of the invention are useful for diagnostic or prognostic purposes include, but are not limited to osteoporosis, osteoarthritis, chondrodysplasia, multiple epiphyseal dysplasia, osteogenesis imperfecta, shortness of stature, scoliosis, low bone density, and degenerative joint disease.
Inventor(s): Prockop; Darwin J. (Philadelphia, PA), Spotila; Loretta D. (Haddonfield, NJ), Deltas; Constantinos D. (Nicosia, CY), Sereda; Larisa (Philadelphia, PA), Westerhausen Larson; Andrea (Forrest Hills, PA), Pack; Michael (Philadelphia, PA), Colige; Alain (Philadelphia, PA), Early; James (Upper Darby, PA), Korkko; Jarmo (Philadelphia, PA), Ala-Kokko; Leena (Oulu, FI), Annunen; Susanna (Oulu, FI), Pihlajamaa; Tero (Oulu, FI), Vuoristo; Mirko (Oulu, FI), Paassilta; Petteri (Oulu, FI)
Assignee: Allegheny University of the Health Sciences (Philadelphia, PA) Thomas Jefferson University (Philadelphia, PA) University of Oulu (Oulu, FI)
Application Number:08/943,731
Patent Claims:see list of patent claims

Details for Patent 6,265,157

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2011-12-03
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2011-12-03
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Merck
Moodys
Baxter
Dow
Boehringer Ingelheim
Johnson and Johnson

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