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Last Updated: September 30, 2020

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Patent: 6,251,388

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Summary for Patent: 6,251,388
Title: Utilization of Wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence
Abstract:Described herein are methods for producing recombinant forms of asparaginase derived from Wolinella succinogenes. In addition, methods for covalent modification of proteins, including asparaginases, by acylation are also provided. Certain embodiments provide for epitopic-labeling of the amino terminus of W. succinogenes asparaginase. Additional embodiments concern methods for the therapeutic utilization of the native, homotetrameric form of W. succinogenes asparaginase, as well as the use of epitopically-labeled or non-epitopically-labeled recombinant W. succinogenes asparaginase (or a covalently modified analog thereof) in the therapeutic treatment of malignant and non-malignant hematological disease and other diseases where asparagine depletion or deprivation would be efficacious or which respond to asparagine depletion or deprivation, as well as their potential utilization in the therapeutic treatment of autoimmune diseases such as rheumatoid arthritis, AIDS, and SLE.
Inventor(s): Durden; Donald L. (Glendale, CA)
Assignee: Childrens Hospital Los Angeles (Los Angeles, CA)
Application Number:09/094,435
Patent Claims:see list of patent claims

Details for Patent 6,251,388

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Childrens Hospital Los Angeles (Los Angeles, CA) 2017-06-09 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Medtronic
Johnson and Johnson
Merck
McKesson
Harvard Business School
Boehringer Ingelheim

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