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Last Updated: November 29, 2021

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Patent: 6,248,767

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Summary for Patent: 6,248,767
Title: Formulation of sulfonamides for treatment of endothelin-mediated disorders
Abstract:Formulations of pharmaceutically-acceptable salts of thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides using the formulations are provided. In particular, formulations of sodium salts of N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamide salts for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide salt are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamide salts or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
Inventor(s): Blok; Natalie (Houston, TX), Wu; Chengde (Houston, TX), Woodard; Patricia (Sugarland, TX), Keller; Karin (Houston, TX), Kogan; Timothy (Sugarland, TX)
Assignee: Texas Biotechnology Corp. (Houston, TX)
Application Number:08/938,444
Patent Claims:see list of patent claims

Details for Patent 6,248,767

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live For Injection 125123 2006-05-25 ⤷  Try it Free 2013-05-20
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Mallinckrodt
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Medtronic
Merck
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