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Last Updated: February 18, 2020

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Patent: 6,232,094

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Summary for Patent: 6,232,094
Title: DNA encoding human .kappa. casein and process for obtaining the protein
Abstract:The present invention relates to an expression system comprising a DNA sequence encoding a polypeptide which has a biological activity of human .kappa.-casein, the system comprising a 5\'-flanking sequence capable of mediating expression of said DNA sequence. In preferred embodiments the 5\'-flanking sequence is from a milk protein gene of a mammal such as a casein gene or whey acidic protein (WAP) gene and the DNA sequence contains at least one intron sequence selected from the intron sequences presented in SEQ ID NO:30. The invention also relates to DNA sequences, replicable expression vectors and cells harboring said vectors, recombinant polypeptide e.g. in glycosylated form, and milk, infant formula or nutrient supplement comprising recombinant polypeptide. The invention further relates to a transgenic non-human mammal such as a mouse, rat, rabbit, goat, sheep, pig, lama, camel or bovine species whose germ cells and somatic cells contain a DNA sequence as defined above as a result of chromosomal incorporation into the non-human mammalian genome, or into the genome of an ancestor of said non-human mammal.
Inventor(s): Hansson; Lennart (Umea, SE), Stromqvist; Mats (Umea, SE), Bergstrom; Sven (Umea, SE), Hernell; Olle (Umea, SE), Tornell; Jan (Vastra Frolunda, SE)
Assignee: Symbicom Aktiebolag (Umea, SE)
Application Number:08/462,437
Patent Claims:see list of patent claims

Details for Patent 6,232,094

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Symbicom Aktiebolag (Umea, SE) 2018-05-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Symbicom Aktiebolag (Umea, SE) 2018-05-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Symbicom Aktiebolag (Umea, SE) 2018-05-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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