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Last Updated: October 1, 2020

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Patent: 6,222,094

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Summary for Patent: 6,222,094
Title: Transgenic non-human mammal expressing the DNA sequence encoding kappa casein mammary gland and milk
Abstract:The present invention relates to an expression system comprising a DNA sequence encoding a polypeptide which ha a biological activity of human .kappa.-casein, the system comprising a 5\'-flanking sequence capable of mediating expression of said DNA sequence. In preferred embodiments the 5\'-flanking sequence is from a milk protein gene of a mammal such as a casein gene or whey acidic protein (WAP) gene and the DNA sequence contains at least one intron sequence. The invention further relates to DNA sequences, replicable expression vectors and cells harboring said vectors, recombinant polypeptide e.g. in glycosylated form, and milk, infant formula or nutrient supplement comprising recombinant polypeptide. The invention also relates to a method for producing a transgenic non-human mammal comprising injecting an expression system as defined above and optionally a further DNA encoding .beta.-casein or an analog, variant or subsequence thereof into a fertilized egg or a cell of an embryo of a mammal so as to incorporate the expression system into the germline of the mammal and developing the resulting injected fertilized egg or embryo into an adult female mammal. In one embodiment, the endogenous polypeptide expressing capability of the mammal is destroyed and/or replaced with the expression system defined above. The invention further relates to a transgenic non-human mammal such as a mouse, rat, rabbit, goat, sheep, pig, lama, camel or bovine species whose germ cells a somatic cells contain a DNA sequence as defined above as a result of chromosomal incorporation into the non-human mammalian genome, or into the genome of an ancestor of said non-human mammal.
Inventor(s): Hansson; Lennart (Ume.ang., SE), Stromqvist; Mats (Ume.ang., SE), Bergstrom; Sven (Ume.ang., SE), Hernell; Olle (Ume.ang., SE), Tornell; Jan (Vastra, SE)
Assignee: Symbicom Aktiebolag (Umea, SE)
Application Number:08/256,799
Patent Claims:see list of patent claims

Details for Patent 6,222,094

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Symbicom Aktiebolag (Umea, SE) 2018-04-24 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Symbicom Aktiebolag (Umea, SE) 2018-04-24 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Symbicom Aktiebolag (Umea, SE) 2018-04-24 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Mallinckrodt
Baxter
Moodys
Merck
McKesson

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