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Serving hundreds of leading biopharmaceutical companies globally:

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Generated: September 23, 2019

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Patent: 6,204,012

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Summary for Patent: 6,204,012
Title: Protein production process
Abstract:A method for producing a protein by culturing a cell capable of expressing the protein and which contains a methylotrophic yeast promoter for an enzyme of the methanol metabolic pathway controlling expression of the protein, in a fermentative batch process comprising a batch phase and a feeding phase, under conditions such that dissolved oxygen is continually present in the culture medium throughout the process, and about 1% to about 100% of the carbon source during the feeding phase is a sugar or sugar polymer, which sugar or sugar polymer is provided in such an amount that the sugar or sugar polymer is continually depleted by the cell and therefore is substantially undetectable in the culture medium; and isolating the protein on completion of the feeding phase.
Inventor(s): Hellmuth; Karsten (Marklohe, DE), Lopez-Ulibarri; Rual (Montclair, NJ), Mayer; Anne Fran.cedilla.oise (New York, NY), Schlieker; Heinrich Winfried (Bloomfield, NJ), van Loon; Adolphus (Rheinfelden, CH)
Assignee: Roche Vitamins Inc. (Parsippany, NJ)
Application Number:09/163,052
Patent Claims:see list of patent claims

Details for Patent 6,204,012

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up Roche Vitamins Inc. (Parsippany, NJ) 2017-10-01 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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