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Generated: September 22, 2019

DrugPatentWatch Database Preview

Patent: 6,194,176

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Summary for Patent: 6,194,176
Title: Recombinant expression of proteins from secretory cell lines
Abstract:The present invention a provides methods for production of heterologous polypeptides using a variety recombinantly engineered secretory cell lines. The common feature of these cell lines is the absence of expression of at least one endogenous polypeptide. The host cell machinery normally used to produce the endogenous polypeptide is then usurped for the purpose of making the heterologous polypeptide. Also described are methods engineering cells for high level expression, methods of large scale protein production, and methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines.
Inventor(s): Newgard; Christopher B. (Dallas, TX), Halban; Philippe (Geneva, CH), Normington; Karl D. (Dallas, TX), Clark; Samuel A. (Rockwell, TX), Thigpen; Anice E. (Dallas, TX), Quaade; Christian (Dallas, TX), Kruse; Fred (Dallas, TX)
Assignee: Board of Regents, The University of Texas System (Austin, TX) Betagene, Inc. (Dallas, TX)
Application Number:08/785,271
Patent Claims:see list of patent claims

Details for Patent 6,194,176

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Try a Free Trial Board of Regents, The University of Texas System (Austin, TX) Betagene, Inc. (Dallas, TX) 2016-01-19 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Try a Free Trial Board of Regents, The University of Texas System (Austin, TX) Betagene, Inc. (Dallas, TX) 2016-01-19 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Try a Free Trial Board of Regents, The University of Texas System (Austin, TX) Betagene, Inc. (Dallas, TX) 2016-01-19 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Try a Free Trial Board of Regents, The University of Texas System (Austin, TX) Betagene, Inc. (Dallas, TX) 2016-01-19 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Try a Free Trial Board of Regents, The University of Texas System (Austin, TX) Betagene, Inc. (Dallas, TX) 2016-01-19 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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