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Generated: August 21, 2019

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Patent: 6,140,059

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Summary for Patent: 6,140,059
Title: Methods for the obtention of human immunodeficiency virsus Type 1 envelope glycoproteins in native and oligomeric form employing recombinant chimeric antigens containing collagenase recognition sites.
Abstract:The present invention is relative to a method for the obtention of native domains of viral membrane proteins, especially of native, that is, oligomeric and glycosylated ectodomains of the surface protein gp160 of the human immunodeficiency virus HIV, the causative agent of AIDS (acquired immune deficiency syndrome), as well as the native protein domains themselves obtained by this method, especially native ectodomains of the env glycoprotein of HIV whose monomers exhibit an electrophoretic mobility of approximately 140 kD as well as their use as vaccine, especially as vaccine against HIV. A nucleotide sequence coding for a recognition sequence for protein-splitting enzymes is inserted at a suitable site into the gene coding for the precursor protein of the protein domain to be obtained. After expression of the gene mutant in eukaryotic cells a digestion with a suitable enzyme is carried out and the protein domain to be obtained is subsequently purified.
Inventor(s): Schawaller; Manfred (D-75210 Keltern-Dietlingen, DE)
Application Number:08/448,619
Patent Claims:see list of patent claims

Details for Patent 6,140,059

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04   Try a Free Trial 2013-01-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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