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Last Updated: September 30, 2020

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Patent: 6,132,976

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Summary for Patent: 6,132,976
Title: Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
Abstract:The present invention relates to a method for detecting cartilage degradation in a biological sample by identifying the presence of unwound type II collagen in the biological sample, said method comprising: contacting the biological sample with a monoclonal antibody which does not bind to native helical collagen but which does bind to an epitope on unwound type II collagen chains or fragments thereof, wherein said epitope has the following sequence (SEQ ID NO: 4): detecting the presence of the bound monoclonal antibody. The present invention also relates to a method for detecting collagenase induced cartilage degradation in a biological sample by identifying the presence of an epitope on type II collagen which only becomes detectable following cleavage of said collagen by collagenase, said method comprising: contacting the biological sample with a monoclonal antibody which binds to said epitope on type II collagen chains or fragments thereof containing said epitope; and detecting the presence of said monoclonal antibody bound to the type II collagen and fragments.
Inventor(s): Poole; Anthony Robin (Baie d\'Urfe, CA), Hollander; Anthony Peter (Greystones, GB), Billinghurst; R. Clark (Fort Collins, CO)
Assignee: Shriners Hospitals for Children (Tampa, FL)
Application Number:09/010,999
Patent Claims:see list of patent claims

Details for Patent 6,132,976

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Shriners Hospitals for Children (Tampa, FL) 2012-12-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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