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Generated: July 21, 2019

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Patent: 6,130,063

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Summary for Patent: 6,130,063
Title: DNA sequences, vectors, and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
Abstract:The invention includes novel fusion DNA sequences encoding fusion polypeptides which when expressed in a filamentous fungus result in the expression of fusion polypeptides which when secreted result in increased levels of secretion of the desired polypeptide as compared to the expression and secretion of such polypeptides from filamentous fungi transformed with previously used DNA sequences. The fusion DNA sequences comprise from the 5\' terminus four DNA sequences which encode a fusion polypeptide comprising, from the amino to carbonyl-terminus, first, second, third and fourth amino acid sequences. The first DNA sequence encodes a signal peptide functional as a secretory sequence in a first filamentous fungus. The second DNA sequence encodes a secreted polypeptide or portion thereof which is normally secreted from the same filamentous fungus or a second filamentous fungus. The third DNA sequence encodes a cleavable linker polypeptide while the fourth DNA sequence encodes a desired polypeptide. When the fusion DNA sequence is expressed either in the first or second filamentous fungus, increased secretion of the desired polypeptide is obtained as compared to that which is obtained when the desired polypeptide is expressed from DNA sequences encoding a fusion polypeptide which does not contain the second polypeptide normally secreted from either of the filamentous fungi.
Inventor(s): Lawlis; Virgil Bryan (San Mateo, CA)
Assignee: Genencor International, Inc. (Palo Alto, CA)
Application Number:08/828,152
Patent Claims:see list of patent claims

Details for Patent 6,130,063

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up Genencor International, Inc. (Palo Alto, CA) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 6,130,063

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 9015860 Dec 27, 1990
United States of America 2002061560 May 23, 2002
United States of America 2003044955 Mar 06, 2003
United States of America 2003224482 Dec 04, 2003
United States of America 2003224489 Dec 04, 2003
United States of America 5364770 Nov 15, 1994
Country Patent Number Publication Date

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