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Last Updated: September 28, 2020

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Patent: 6,110,892

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Summary for Patent: 6,110,892
Title: Parathyroid hormone analogues for the treatment of osteoporosis
Abstract:This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailabilities. The peptides described are derivatives of hPTH-(1-31) which are cyclized for example, by formation of lactams between either Glu.sup.22 and Lys.sup.26 or Lys.sup.26 and Asp.sup.30. In addition, the natural Lys.sup.27 may be substituted by either a Leu or other hydrophobic residues, such as Ile, norleucine, Met, Val, Ala, Trp, or Phe. Typically, these analogues have enhanced abilities to stimulate adenylyl cyclase in rat osteosarcoma cells, and show increased activities in bone restoration, using the ovariectomized rat model. The analogues also show enhanced activities and bioavailabilities, as demonstrated by their hypotensive effects in the rat. An assay which correlates hypotensive activity with osteogenic activity is also described.
Inventor(s): Barbier; Jean-Rene (Gatineau, CA), Morley; Paul (Ottawa, CA), Neugebauer; Witold (Ottawa, CA), Ross; Virginia J. S. (Gloucester, CA), Whitfield; James F. (Ottawa, CA), Willick; Gordon E. (Orleans, CA)
Assignee: National Research Council of Canada (Ottawa, CA)
Application Number:08/904,760
Patent Claims:see list of patent claims

Details for Patent 6,110,892

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial National Research Council of Canada (Ottawa, CA) 2014-06-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial National Research Council of Canada (Ottawa, CA) 2014-06-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial National Research Council of Canada (Ottawa, CA) 2014-06-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial National Research Council of Canada (Ottawa, CA) 2014-06-20 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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