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Generated: September 23, 2019

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Patent: 6,110,738

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Summary for Patent: 6,110,738
Title: Human fast-1 gene
Abstract:hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-.beta. receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-.beta. family. The invention includes tools for investigating the TGF-.beta. signaling pathway and screening for compounds which modulate the action of TGF-.beta..
Inventor(s): Zhou; Shibin (Cockeysville, MD), Zawel; Leigh (Bowie, MD), Vogelstein; Bert (Baltimore, MD), Kinzler; Kenneth W. (BelAir, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Application Number:09/113,309
Patent Claims:see list of patent claims

Details for Patent 6,110,738

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up The Johns Hopkins University (Baltimore, MD) 2037-11-19 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up The Johns Hopkins University (Baltimore, MD) 2037-11-19 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up The Johns Hopkins University (Baltimore, MD) 2037-11-19 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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