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Last Updated: October 1, 2020

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Patent: 6,093,393

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Summary for Patent: 6,093,393
Title: Methods for preparing and using clonogenic fibroblasts and transfected clonogenic fibroblasts
Abstract:The invention relates to a process for preparing clonogenic fibroblasts, with tissue being removed from the donor and the individual cells being isolated from the tissue, the resulting cell suspension being strained, the cells which are contained in the cell suspension being washed and the cells being converted into a tissue culture, with the exception of the isolation of individual cells by mechanical comminution, followed by an enzymic treatment with collagenase alone, and with at least one gene being inserted into the fibroblasts by means of the transfection, which gene encodes a biologically active protein, preferably a therapeutically active protein, for example a growth factor, a hormone, an enzyme, a coagulation factor or a coagulation inhibitor.
Inventor(s): Rosenthal; Felicia (79102 Freiburg, DE), Lindemann; Albrecht (79294 Solden, DE), Boehm; Thomas (79279 Vorstetten, DE), Mertelsmann; Roland (79104 Freiburg, DE), Veelken; Hendrik (79110 Freiburg, DE), Kulmburg; Peter (79110 Freiburg, DE)
Assignee:
Application Number:08/700,506
Patent Claims:see list of patent claims

Details for Patent 6,093,393

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial 2014-02-24 RX search
Akorn Inc HYDASE hyaluronidase INJECTABLE;INJECTION 021716 001 2005-10-25   Start Trial 2014-02-24 DISCN search
Amphastar Pharm AMPHADASE hyaluronidase INJECTABLE;INJECTION 021665 001 2005-11-03   Start Trial 2014-02-24 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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