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Generated: July 16, 2019

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Patent: 6,087,129

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Summary for Patent: 6,087,129
Title: Recombinant expression of proteins from secretory cell lines
Abstract:The present invention a provides methods for production of heterologous polypeptides using a variety recombinantly engineered secretory cell lines. The common feature of these cell lines is the absence of expression of at least one endogenous polypeptide. The host cell machinery normally used to produce the endogenous polypeptide is then usurped for the purpose of making the heterologous polypeptide. Also described are methods engineering cells for high level expression, methods of large scale protein production, and methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines.
Inventor(s): Newgard; Christopher B. (Dallas, TX), Normington; Karl D. (Dallas, TX), Clark; Samuel A. (Rockwall, TX), Thigpen; Anice E. (Dallas, TX), Quaade; Christian (Dallas, TX), Kruse; Fred (Dallas, TX)
Assignee: Betagene, Inc. (Dallas, TX) Board of Regents, The University of Texas System (Austin, TX)
Application Number:08/589,028
Patent Claims:see list of patent claims

Details for Patent 6,087,129

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Try a Free Trial Betagene, Inc. (Dallas, TX) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Try a Free Trial Betagene, Inc. (Dallas, TX) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Try a Free Trial Betagene, Inc. (Dallas, TX) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Try a Free Trial Betagene, Inc. (Dallas, TX) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX Orphan search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Try a Free Trial Betagene, Inc. (Dallas, TX) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Try a Free Trial Betagene, Inc. (Dallas, TX) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 6,087,129

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 9726321 Jan 08, 1998
World Intellectual Property Organization (WIPO) 9726321 Jul 24, 1997
World Intellectual Property Organization (WIPO) 9726334 Jul 24, 1997
United States of America 6110707 Aug 29, 2000
United States of America 6194176 Feb 27, 2001
European Patent Office 0876484 Nov 11, 1998
Country Patent Number Publication Date

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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
Citi
Express Scripts
McKinsey
Federal Trade Commission
Colorcon

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