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Last Updated: September 23, 2020

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Patent: 6,080,589

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Summary for Patent: 6,080,589
Title: Neisseria meningitidis capsular polysacchride conjugates
Abstract:Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant reactive residues of heterobifunctional linker molecules to the polysaccharide backbone. The capsular polysaccharide is deacetylated and the heterobifunctional linker molecule is reacted with the deacetylated material and any residual amino groups are blocked by reaction with alkyl acid anhydride. The introduction of the linker molecules to the polysaccharide chain between the termini enables the polysaccharide to be linked to a carrier molecule, such as a protein, to enhance the immunogenicity of the polysaccharide. The conjugate molecule may be formulated as an immunogenic composition for raising antibodies in a host to the polysaccharide.
Inventor(s): Kandil; Ali (Willowdale, CA), Chong; Pele (Richmond Hill, CA), Klein; Michel H. (Willowdale, CA)
Assignee: Connaught Laboratories Limited (North York, CA)
Application Number:09/061,189
Patent Claims:see list of patent claims

Details for Patent 6,080,589

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Recordati Rare Diseases, Inc. PANHEMATIN hemin POWDER, FOR SOLUTION 101246 1 1983-07-20   Start Trial Connaught Laboratories Limited (North York, CA) 2015-06-07 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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