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Last Updated: September 26, 2020

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Patent: 6,080,580

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Summary for Patent: 6,080,580
Title: Antisense oligonucleotide modulation of tumor necrosis factor-.alpha. (TNF-.alpha.) expression
Abstract:Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-.alpha. (TNF-.alpha.). Antisense oligonucleotides targeted to nucleic acids encoding TNF-.alpha. are preferred. Methods of using these oligonucleotides for inhibition of TNF-.alpha. expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-.alpha. are provided.
Inventor(s): Baker; Brenda F. (Carlsbad, CA), Bennett; C. Frank (Carlsbad, CA), Butler; Madeline M. (Rancho Santa Fe, CA), Shanahan, Jr.; William R. (Encinitas, CA)
Assignee: Isis Pharmaceuticals Inc. (Carlsbad, CA)
Application Number:09/166,186
Patent Claims:see list of patent claims

Details for Patent 6,080,580

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Isis Pharmaceuticals Inc. (Carlsbad, CA) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Isis Pharmaceuticals Inc. (Carlsbad, CA) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Isis Pharmaceuticals Inc. (Carlsbad, CA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Baxter

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