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Last Updated: September 27, 2020

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Patent: 6,071,923

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Summary for Patent: 6,071,923
Title: Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases
Abstract:This invention relates to the novel retinoyloxy(aryl-substituted)-alkylene butyrate compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising administering a compound of Formula (I) and pharmaceutically-acceptable salts and prodrugs thereof. ##STR1## The compounds of the invention are also useful in methods of inhibiting histone deacetylase, ameliorating wrinkles, treating or ameliorating dermatological disorders, inducing wound healing, treating cutaneous ulcers and treating gastrointestinal disorders.
Inventor(s): Nudelman; Abraham (Rehovot, IL), Rephaeli; Ada (Herzelia, IL)
Assignee: Bar-Ilan University (Ramat-Gan, IL) Mor Rese Applications (Givat Shmuel, IL)
Application Number:08/883,219
Patent Claims:see list of patent claims

Details for Patent 6,071,923

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Bar-Ilan University (Ramat-Gan, IL) Mor Rese Applications (Givat Shmuel, IL) 2014-09-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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